Comino (Maltese: Kemmuna) is an island of the Maltese archipelago between the islands of Malta and Gozo in the Mediterranean Sea, measuring 1.35 sq. miles in area. Named after the cumin herb that once flourished on the Island, Comino is noted for its tranquility and isolation. It has a permanent population of only four residents. One priest and one policeman commute from the nearby island of Gozo, to render their services to the local population and summertime visitors. Today, Comino is a bird sanctuary and nature reserve. Administratively it is part of the municipality ofGħajnsielem, in southeastern Gozo.

Comino is known to have been inhabited by farmers during Roman times, however for long periods in its history it has been sparsely populated, or abandoned entirely.

Its rugged coastline is delineated by sheer limestone cliffs, and dotted with deep caves which were popular with pirates and marauders in the Middle Ages. The caves and coves of Comino were frequently used as staging posts for raids on hapless boats crossing between Malta and Gozo. In later years, the Knights of Malta used this island as hunting and recreational grounds. The Knights were fiercely protective of the local game, which consisted of wild boar and hares (Maltese: fenek tal-grixti): upon conviction, poachers were liable to a penalty of three years as a galley slave.

In the 16th and 17th centuries, Comino served as a place of imprisonment or exile for errant knights. Knights who were convicted of minor crimes were occasionally sentenced to the lonely and dangerous task of manning St. Mary's Tower.